MED4 and PUM2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)

		MED4	PUM2
Description		mediator complex subunit 4	pumilio RNA binding family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coregulator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated	Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Stress Granule Assembly Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of MRNA Stability Regulation Of Chromosome Segregation Regulation Of Gene Silencing By MiRNA Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of Gene Silencing By MiRNA
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Neddylation
Drugs
Diseases
GWAS		Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)	Body mass index ( 28892062)
Interacting Genes		33 interacting genes: AMOT AP2M1 ATF7IP C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TXLNA USHBP1 WDTC1	8 interacting genes: AURKA DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 NANOS1
Entrez ID		29079	23369
HPRD ID		16145	09527
Ensembl ID		ENSG00000136146	ENSG00000055917
Uniprot IDs		A0A024RDY7 Q9NPJ6	A0A0A0MR59 B7ZL34 Q8TB72
PDB IDs			3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?
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