MED4 and FTCD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MED4	FTCD
Description		mediator complex subunit 4	formimidoyltransferase cyclodeaminase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Cytosol Plasma Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding Folic Acid Binding Microtubule Binding Formimidoyltransferase Activity Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated	Histidine Catabolic Process Folic Acid-containing Compound Metabolic Process Cytoskeleton Organization Histidine Catabolic Process To Glutamate And Formamide Histidine Catabolic Process To Glutamate And Formate Tetrahydrofolate Interconversion
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Histidine catabolism
Drugs			Pyridoxal Phosphate Tetrahydrofolic acid Glutamic Acid (6R)-Folinic acid
Diseases
GWAS		Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)	Blood protein levels ( 30072576)
Interacting Genes		33 interacting genes: AMOT AP2M1 ATF7IP C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TXLNA USHBP1 WDTC1	3 interacting genes: HDAC2 KASH5 MED4
Entrez ID		29079	10841
HPRD ID		16145	08430
Ensembl ID		ENSG00000136146	ENSG00000160282
Uniprot IDs		A0A024RDY7 Q9NPJ6	O95954
PDB IDs
Enriched GO Terms of Interacting Partners?
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