ARRDC3 and OTUB2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ARRDC3	OTUB2
Description		arrestin domain containing 3	OTU deubiquitinase, ubiquitin aldehyde binding 2
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GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Plasma Membrane	Nucleus
	Molecular Function	Protein Binding Beta-3 Adrenergic Receptor Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Binding
	Biological Process	Temperature Homeostasis Negative Regulation Of Heat Generation Skin Development Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Cold-induced Thermogenesis	Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways			Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Breast cancer ( 29059683 25038754) Breast cancer (prognosis) ( 23319801) Breast cancer (survival) ( 25526632) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		14 interacting genes: ADRB2 BAG3 DCUN1D1 F2R HPGDS ITCH MAGI2 MORF4L1 OTUB2 PDCD6IP STAM2 TNFAIP3 TRIM42 UBE2E2	35 interacting genes: APP ARRDC3 CPSF6 FAM168A GLI2 KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 PJA1 RBCK1 REL RFFL RNF126 SIAH1 TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 U2AF2 UBC UBE2N USP21 USP28
Entrez ID		57561	78990
HPRD ID		09810	07620
Ensembl ID		ENSG00000113369	ENSG00000089723
Uniprot IDs		Q96B67	Q96DC9
PDB IDs		4N7H 4R7V 4R7X	1TFF 4FJV
Enriched GO Terms of Interacting Partners?
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