MAP2K6 and MAP2K4

  • Number of citations of the paper that reports this interaction (PubMedID 15866172)
  • 45
  • Data Source:
  • BioGRID (enzymatic study)

MAP2K6

MAP2K4

Description mitogen-activated protein kinase kinase 6 mitogen-activated protein kinase kinase 4
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872)
  • Optic disc size ( 31809533)
  • Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482)
  • Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225)
  • Waist-hip ratio ( 28552196)
  • Estimated glomerular filtration rate ( 31152163)
  • Response to amphetamines ( 22952603)
Interacting Genes 37 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K3 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6 39 interacting genes: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 TRIB1 UBC
Entrez ID 5608 6416
HPRD ID 03155 03213
Ensembl ID ENSG00000108984 ENSG00000065559
Uniprot IDs A0A024R8K3 A8K3Y2 P52564 P45985
PDB IDs 2Y8O 3ENM 3FME 3VN9 5ETF 3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?
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