MAP2K6 and MAP2K4

Number of citations of the paper that reports this interaction (PubMedID 15866172)
45

Data Source:
BioGRID (enzymatic study)

		MAP2K6	MAP2K4
Description		mitogen-activated protein kinase kinase 6	mitogen-activated protein kinase kinase 4
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton	Nucleus Cytoplasm Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Response To Ischemia Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Regulation Of Mitotic Cell Cycle Peptidyl-tyrosine Phosphorylation Ovulation Cycle Process Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Prostaglandin Secretion Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cardiac Muscle Contraction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Sorbitol Negative Regulation Of Cold-induced Thermogenesis	Activation Of MAPK Activity Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Response To Wounding Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)	Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603)
Interacting Genes		37 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K3 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6	39 interacting genes: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 TRIB1 UBC
Entrez ID		5608	6416
HPRD ID		03155	03213
Ensembl ID		ENSG00000108984	ENSG00000065559
Uniprot IDs		A0A024R8K3 A8K3Y2 P52564	P45985
PDB IDs		2Y8O 3ENM 3FME 3VN9 5ETF	3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?
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