MAP2K4 and ARRB2

Number of citations of the paper that reports this interaction (PubMedID 11090355)
226

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		MAP2K4	ARRB2
Description		mitogen-activated protein kinase kinase 4	arrestin beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axon Dendrite Cytoplasm Perikaryon	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Postsynaptic Density Basolateral Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Intracellular Membrane-bounded Organelle Postsynaptic Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Type 1 Angiotensin Receptor Binding D1 Dopamine Receptor Binding Follicle-stimulating Hormone Receptor Binding Type 2A Serotonin Receptor Binding Platelet Activating Factor Receptor Binding Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding Molecular Adaptor Activity 14-3-3 Protein Binding Arrestin Family Protein Binding
	Biological Process	Activation Of MAPK Activity Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Response To Wounding Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Negative Regulation Of Motor Neuron Apoptotic Process	Negative Regulation Of Protein Phosphorylation G Protein-coupled Receptor Internalization Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Brain Development Adult Walking Behavior Positive Regulation Of Gene Expression Protein Transport Protein Ubiquitination Protein Deubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Follicle-stimulating Hormone Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Excitatory Postsynaptic Potential Cell Chemotaxis Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603)	Lymphocyte counts ( 27863252)
Interacting Genes		39 interacting genes: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 TRIB1 UBC	51 interacting genes: ADRB2 AGTR1 AP1B1 AP2M1 ARF6 AVPR2 C5AR1 CDC42 CLTC CSNK2A1 CSNK2A2 CXCR4 CYTH2 DVL2 EGFR FLNA FZD4 GRK2 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MDM2 MED8 NDUFS7 NFKBIA NTS NTSR1 OPRD1 OXER1 OXTR PDE4D PRKN PTAFR PTGDS RAF1 RALGDS RHO SLC9A5 SMARCC2 STC2 TGFBR3 TRH UBC
Entrez ID		6416	409
HPRD ID		03213	00147
Ensembl ID		ENSG00000065559	ENSG00000141480
Uniprot IDs		P45985	K7ENA6 P32121 Q59EM5 Q68DZ5
PDB IDs		3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?
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