MAP2K4 and MAPK8IP3

Number of citations of the paper that reports this interaction (PubMedID 12189133)
26

Data Source:
HPRD (in vivo, in vitro)

		MAP2K4	MAPK8IP3
Description		mitogen-activated protein kinase kinase 4	mitogen-activated protein kinase 8 interacting protein 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axon Dendrite Cytoplasm Perikaryon	Golgi Membrane Cytoplasm Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Body Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	Activation Of MAPK Activity Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Response To Wounding Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Negative Regulation Of Motor Neuron Apoptotic Process	Activation Of JUN Kinase Activity Vesicle-mediated Transport Axon Regeneration Regulation Of JNK Cascade Axon Development Anterograde Axonal Protein Transport
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603)	Intraocular pressure ( 29617998)
Interacting Genes		39 interacting genes: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 TRIB1 UBC	23 interacting genes: ARL4D CASP3 KLC1 KLC2 LDLRAP1 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 PTK2 RAD51 RAF1 RIC8A SRC TLR2 TLR4 TLR9
Entrez ID		6416	23162
HPRD ID		03213	12014
Ensembl ID		ENSG00000065559	ENSG00000138834
Uniprot IDs		P45985	A0A087WYG2 B7ZMF3 E9PFH7 Q9UPT6
PDB IDs		3ALN 3ALO 3VUT	4PXJ
Enriched GO Terms of Interacting Partners?
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