PKN2 and CCDC136

  • Number of citations of the paper that reports this interaction (PubMedID 21900206)
  • 114
  • Data Source:
  • BioGRID (two hybrid)

PKN2

CCDC136

Description protein kinase N2 coiled-coil domain containing 136
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)
  • Coronary artery disease ( 29212778)
  • Diastolic blood pressure ( 27841878)
  • General risk tolerance (MTAG) ( 30643258)
  • Heel bone mineral density ( 30598549 28869591)
  • Height ( 20881960 25282103 31562340)
  • Intraocular pressure ( 29617998)
  • Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
  • Narcolepsy ( 23459209)
  • Paclitaxel disposition in epithelial ovarian cancer ( 29367611)
  • Periodontal microbiota ( 22699663)
  • Photic sneeze reflex ( 27182965)
  • Pulse pressure ( 27841878)
  • Response to fenofibrate (LDL cholesterol levels) ( 27002377)
  • Rosacea symptom severity ( 29771307)
  • Serum protein levels (sST2) ( 23999434)
  • Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
  • Systolic blood pressure ( 30224653 27841878)
  • Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
  • Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
  • Reading disability or specific language impairment (pleiotropy) ( 25065397)
  • Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes 18 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTBP2 PTPN13 RHOA 64 interacting genes: ABT1 AQP1 ATP5PO ATXN1 BARD1 BLOC1S6 BYSL C1orf216 CBX8 CCDC146 CCHCR1 CDC5L CDK2AP1 CEP57L1 COIL CWF19L2 DISC1 ENKD1 FAM107A FAM161A GFI1B HAUS1 HDAC4 HGS HMG20A HMG20B JMY KANSL1 KAT5 KIFC3 LENG1 MAGEB4 MOS NDN NEBL PDLIM5 PKN2 PPP1R18 PRPF31 PSMD9 RAB33A SHFL SMARCE1 TBRG1 TCEA2 TNNT1 TXLNA UBQLN4 USP2 WT1 ZBTB38 ZC2HC1C ZNF20 ZNF230 ZNF250 ZNF408 ZNF417 ZNF490 ZNF564 ZNF572 ZNF581 ZNF587 ZNF688 ZSCAN26
Entrez ID 5586 64753
HPRD ID 03972 10887
Ensembl ID ENSG00000065243 ENSG00000128596
Uniprot IDs Q16513 A0A024R758 Q96JN2
PDB IDs 4CRS 4RRV 6CCY 6GBE
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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