CCDC136 and HGS

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		CCDC136	HGS
Description		coiled-coil domain containing 136	hepatocyte growth factor-regulated tyrosine kinase substrate
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Membrane Integral Component Of Membrane	Lysosome Endosome Early Endosome Cytosol Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function		Protein Binding Protein Domain Specific Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding
	Biological Process	Acrosome Assembly Spermatogenesis Single Fertilization	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Protein Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of MAP Kinase Activity Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways			EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion
Drugs			Citric Acid
Diseases
GWAS		Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	Eye color traits ( 20463881)
Interacting Genes		64 interacting genes: ABT1 AQP1 ATP5PO ATXN1 BARD1 BLOC1S6 BYSL C1orf216 CBX8 CCDC146 CCHCR1 CDC5L CDK2AP1 CEP57L1 COIL CWF19L2 DISC1 ENKD1 FAM107A FAM161A GFI1B HAUS1 HDAC4 HGS HMG20A HMG20B JMY KANSL1 KAT5 KIFC3 LENG1 MAGEB4 MOS NDN NEBL PDLIM5 PKN2 PPP1R18 PRPF31 PSMD9 RAB33A SHFL SMARCE1 TBRG1 TCEA2 TNNT1 TXLNA UBQLN4 USP2 WT1 ZBTB38 ZC2HC1C ZNF20 ZNF230 ZNF250 ZNF408 ZNF417 ZNF490 ZNF564 ZNF572 ZNF581 ZNF587 ZNF688 ZSCAN26	182 interacting genes: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG C1orf94 CASK CBS CCDC103 CCDC114 CCDC136 CCDC33 CDR2 CEP55 CEP57L1 CEP63 CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAJC5 DYDC1 EGFR EHMT2 EPS15 ESRRG EXOC5 EXOC7 EXOC8 FAM168A FANCG FCHSD2 FLOT1 FLOT2 GFAP GFI1B GGA2 GKAP1 GOLGA2 HAP1 HNRNPDL HSFY1 HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KIAA0753 KRT13 KRT15 KRT18 KRT19 KRT31 KRT33B KRT38 KRT40 KRT6A KRTAP26-1 LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD8 NEFL NF2 NMI NPAS2 NUP54 NUP62 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 PMEPA1 PNMA1 POGZ PPP1R16A PPP1R7 PTCD3 RBCK1 RFX6 RHOBTB3 RINT1 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 SS18L1 STAM STAM2 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TEKT1 TFG TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TRAF4 TRAK1 TRAP1 TRIM17 TRIM27 TRIM69 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 ZNF302
Entrez ID		64753	9146
HPRD ID		10887	05085
Ensembl ID		ENSG00000128596	ENSG00000185359
Uniprot IDs		A0A024R758 Q96JN2	A0A0S2Z4R4 O14964
PDB IDs			2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?