PKN2 and MYO9B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		PKN2	MYO9B
Description		protein kinase N2	myosin IXB
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Actin Filament Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity GTP-Rho Binding Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding	Microfilament Motor Activity Actin Binding GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding ATPase Activity Rho GTPase Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Roundabout Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Viral Process Peptidyl-serine Phosphorylation Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility	Rho Protein Signal Transduction Actin Filament-based Movement ARF Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHO GTPases activate PKNs	Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation SLIT2:ROBO1 increases RHOA activity FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 31562340) Intraocular pressure ( 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Narcolepsy ( 23459209) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Periodontal microbiota ( 22699663) Photic sneeze reflex ( 27182965) Pulse pressure ( 27841878) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Rosacea symptom severity ( 29771307) Serum protein levels (sST2) ( 23999434) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure ( 30224653 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) Glycated hemoglobin levels ( 24647736 28898252) Height ( 20881960 31562340 29782485) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Prostate cancer ( 29892016) Prostate cancer (early onset) ( 29892016) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Selective IgA deficiency ( 27723758) Systolic blood pressure ( 27841878 30578418) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		18 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTBP2 PTPN13 RHOA	7 interacting genes: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2 RAB8A
Entrez ID		5586	4650
HPRD ID		03972	03677
Ensembl ID		ENSG00000065243	ENSG00000099331
Uniprot IDs		Q16513	B0I1T6 Q13459 Q4LE74 Q8WVD2
PDB IDs		4CRS 4RRV 6CCY 6GBE	5C5S 5HPY
Enriched GO Terms of Interacting Partners?
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