SHFL and CCDC136

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SHFL	CCDC136
Description		shiftless antiviral inhibitor of ribosomal frameshifting	coiled-coil domain containing 136
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Viral Replication Complex	Acrosomal Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Protein Binding Ribosome Binding Sequence-specific MRNA Binding
	Biological Process	Regulation Of Translational Termination Response To Type I Interferon Response To Interferon-gamma Response To Type III Interferon Response To Interferon-beta Negative Regulation Of Viral Genome Replication Defense Response To Virus Viral Translational Frameshifting Negative Regulation Of Translational Frameshifting	Acrosome Assembly Spermatogenesis Single Fertilization
Pathways
Drugs
Diseases
GWAS			Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		34 interacting genes: ADAMTSL4 CADPS CCDC136 DRICH1 DTNBP1 ECSIT FBXL12 IKZF1 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 LZTS2 MAGEA1 MDFI MEOX2 MID2 MTUS2 NOTCH2NLA PDE4DIP SPRY2 SSX2IP TCF4 TERF1 TNS2 TRAF1	64 interacting genes: ABT1 AQP1 ATP5PO ATXN1 BARD1 BLOC1S6 BYSL C1orf216 CBX8 CCDC146 CCHCR1 CDC5L CDK2AP1 CEP57L1 COIL CWF19L2 DISC1 ENKD1 FAM107A FAM161A GFI1B HAUS1 HDAC4 HGS HMG20A HMG20B JMY KANSL1 KAT5 KIFC3 LENG1 MAGEB4 MOS NDN NEBL PDLIM5 PKN2 PPP1R18 PRPF31 PSMD9 RAB33A SHFL SMARCE1 TBRG1 TCEA2 TNNT1 TXLNA UBQLN4 USP2 WT1 ZBTB38 ZC2HC1C ZNF20 ZNF230 ZNF250 ZNF408 ZNF417 ZNF490 ZNF564 ZNF572 ZNF581 ZNF587 ZNF688 ZSCAN26
Entrez ID		55337	64753
HPRD ID		07747	10887
Ensembl ID		ENSG00000130813	ENSG00000128596
Uniprot IDs		Q9NUL5	A0A024R758 Q96JN2
PDB IDs
Enriched GO Terms of Interacting Partners?
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