UBE2R2 and FBXW5

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		UBE2R2	FBXW5
Description		ubiquitin conjugating enzyme E2 R2	F-box and WD repeat domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Protein Kinase Binding
	Biological Process	Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination	Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 25673413) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787)	Blood protein levels ( 29875488) Heel bone mineral density ( 30598549)
Interacting Genes		25 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 CUL3 DTX3L DZIP3 FBXW5 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 UBA1 UBC	19 interacting genes: ADAMTSL4 FAM168A KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP4-12 KRTAP9-4 MDFI MYB NLK NOTCH2NLA S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2
Entrez ID		54926	54461
HPRD ID		15602	10955
Ensembl ID		ENSG00000107341	ENSG00000159069
Uniprot IDs		Q712K3	A0A024R8H7 Q969U6
PDB IDs		6NYO
Enriched GO Terms of Interacting Partners?
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