UBE2R2 and PNPLA2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		UBE2R2	PNPLA2
Description		ubiquitin conjugating enzyme E2 R2	patatin like phospholipase domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Triglyceride Lipase Activity
	Biological Process	Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination	Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Acylglycerol Acyl-chain Remodeling Post-translational Protein Modification Cellular Protein Metabolic Process Lipid Homeostasis
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 25673413) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787)	Body fat distribution (arm fat ratio) ( 30664634) Keratoconus ( 31855235)
Interacting Genes		25 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 CUL3 DTX3L DZIP3 FBXW5 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 UBA1 UBC	10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		54926	57104
HPRD ID		15602	11443
Ensembl ID		ENSG00000107341	ENSG00000177666
Uniprot IDs		Q712K3	Q96AD5
PDB IDs		6NYO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?