FBXW5 and TSC2

Number of citations of the paper that reports this interaction (PubMedID 18381890)
71

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		FBXW5	TSC2
Description		F-box and WD repeat domain containing 5	TSC complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Binding	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Heart Development Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Anoikis Protein Kinase B Signaling Positive Regulation Of GTPase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitophagy
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Blood protein levels ( 29875488) Heel bone mineral density ( 30598549)	Major depressive disorder ( 29317602) Obesity-related traits ( 23251661)
Interacting Genes		19 interacting genes: ADAMTSL4 FAM168A KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP4-12 KRTAP9-4 MDFI MYB NLK NOTCH2NLA S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2	42 interacting genes: AKT1 AKT2 AKT3 CALM1 CBY2 CCND1 CDKN1B ESR1 FBXL6 FBXW5 GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI NEK1 PAM PIN1 PLK2 PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPS6KA1 SFN SMAD2 SMAD3 SUPT6H TK1 TSC1 UBE3A YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		54461	7249
HPRD ID		10955	01850
Ensembl ID		ENSG00000159069	ENSG00000103197
Uniprot IDs		A0A024R8H7 Q969U6	B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D7Q2
PDB IDs
Enriched GO Terms of Interacting Partners?
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