TTC19 and UPF3B

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TTC19	UPF3B
Description		tetratricopeptide repeat domain 19	UPF3B regulator of nonsense mediated mRNA decay
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Centrosome Midbody Respiratory Chain	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Centriolar Satellite Exon-exon Junction Complex
	Molecular Function	Protein Binding	RNA Binding MRNA Binding Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Mitotic Cytokinesis Mitochondrial Respiratory Chain Complex III Assembly Oxidation-reduction Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Positive Regulation Of Translation
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
Interacting Genes		12 interacting genes: ATXN1 CCDC33 CHMP4A EIF4ENIF1 HPS6 IHO1 L3MBTL3 NAB2 REL SPRED1 UBA1 UPF3B	13 interacting genes: EIF4A3 EIF6 EXOSC4 HBB MAGOH MCRS1 RBBP6 RBM8A SRPK2 TTC19 UPF1 UPF2 XRN1
Entrez ID		54902	65109
HPRD ID		07899	02247
Ensembl ID		ENSG00000011295	ENSG00000125351
Uniprot IDs		A0A024RD83 Q6DKK2	Q9BZI7
PDB IDs			1UW4 2XB2
Enriched GO Terms of Interacting Partners?
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