ALAS1 and USP20

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ALAS1	USP20
Description		5'-aminolevulinate synthase 1	ubiquitin specific peptidase 20
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Cytoplasm Centrosome Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis	Ub-specific processing proteases
Drugs		Pyridoxal Phosphate Pyridoxal Phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Metabolite levels ( 23823483)
Interacting Genes		39 interacting genes: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK EP400 GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B RTL8B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	28 interacting genes: ALAS1 BEND5 BEND7 CLSPN DIO2 FATE1 GTF2IRD1 HIF1A IHO1 LMNA MAGEA11 MAPK6 MDFI PJA1 PLA2G2A PRKACA PRKCI RAD17 SPRY2 STING1 TRIM23 UBC ULK1 USP15 USP21 USP28 VAPB VHL
Entrez ID		211	10868
HPRD ID		00505	07505
Ensembl ID		ENSG00000023330	ENSG00000136878
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q9Y2K6
PDB IDs			6KCZ
Enriched GO Terms of Interacting Partners?
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