ALAS1 and ZFYVE26

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ALAS1	ZFYVE26
Description		5'-aminolevulinate synthase 1	zinc finger FYVE-type containing 26
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Lysosomal Membrane Centrosome Midbody
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process	Mitotic Cytokinesis Double-strand Break Repair Via Homologous Recombination Regulation Of Cytokinesis
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Pyridoxal Phosphate Glycine
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (childhood onset) ( 31036433)
Interacting Genes		39 interacting genes: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK EP400 GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B RTL8B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	19 interacting genes: ALAS1 CEP44 GOLGA2 HNRNPC KRT15 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 MDFI PNMA1 PNMA5 SPAG5 SSX2IP TADA2A TDO2 TFIP11 TRAF1 USHBP1
Entrez ID		211	23503
HPRD ID		00505	15734
Ensembl ID		ENSG00000023330	ENSG00000072121
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q68DK2
PDB IDs
Enriched GO Terms of Interacting Partners?
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