ADAMTSL4 and FARS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ADAMTSL4	FARS2
Description		ADAMTS like 4	phenylalanyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure
GO Annotations	Cellular Component	Interstitial Matrix Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protease Binding Protein Binding Peptidase Activity	TRNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	Epithelial Cell Development Proteolysis Apoptotic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation TRNA Processing
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Mitochondrial tRNA aminoacylation
Drugs			L-Phenylalanine
Diseases		Ectopia lentis
GWAS		Coronary artery disease ( 29212778) Migraine ( 27322543) Rhegmatogenous retinal detachment ( 23585552)	Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Copper levels ( 26025379) Height ( 28552196) JT interval (sulfonylurea treatment interaction) ( 27958378) Metabolite levels ( 23823483) Obesity (early onset extreme) ( 23563609) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
Interacting Genes		110 interacting genes: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 CATSPER1 CCDC26 CFAP206 CHCHD2 CHRNG CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL2 GNE GNMT GOLGA8EP HGF HNRNPLL HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LHX4 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 OTX1 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SHFL SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587	23 interacting genes: ADAMTSL4 AGTRAP APPL1 CALCOCO2 CMTM5 HMBOX1 IKZF3 KRT13 KRT31 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-9 MID2 MKRN3 NOTCH2NLA RCBTB2 STX11 TADA2A TFCP2 TRIM27 TRIM54
Entrez ID		54507	10667
HPRD ID		18237	09946
Ensembl ID		ENSG00000143382	ENSG00000145982
Uniprot IDs		B7ZMJ3 Q6UY14 Q9UFG7	O95363
PDB IDs			3CMQ 3HFV 3TEG 3TUP 5MGH 5MGU 5MGV 5MGW
Enriched GO Terms of Interacting Partners?
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