POU1F1 and PITX1

Number of citations of the paper that reports this interaction (PubMedID 8755540)
40

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		POU1F1	PITX1
Description		POU class 1 homeobox 1	paired like homeodomain 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Determination Of Adult Lifespan Cell Differentiation B Cell Differentiation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Multicellular Organism Growth Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Somatotropin Secreting Cell Development	Skeletal System Development Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development
Pathways
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Congenital clubfoot; Congenital talipes equinovarus
GWAS		Menarche (age at onset) ( 25231870) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 30529582 24836286 23263487) Colorectal cancer or advanced adenoma ( 30510241) Height ( 20881960 25429064 23563607 31562340 18391951) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)
Interacting Genes		12 interacting genes: CREBBP ETS1 GATA2 JUN NCOR1 NR1I2 NR1I3 NR3C1 PITX1 PPARA PPARG VDR	27 interacting genes: ALG13 C1orf94 CDX4 DVL3 EGR1 FOXO1 GOLGA2 HGS IPO13 LZTS2 MAGED1 MGAT5B NEUROD1 NR5A1 PLSCR1 POU1F1 PRR20A RBPMS RFX6 RHOXF2 RNF31 SMARCA2 SPAG8 TRAPPC2 TRIM23 UPF2 ZBTB32
Entrez ID		5449	5307
HPRD ID		01409	03688
Ensembl ID		ENSG00000064835	ENSG00000069011
Uniprot IDs		P28069	P78337 X5D9A5
PDB IDs		5WC9
Enriched GO Terms of Interacting Partners?
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