PITX1 and POU1F1

Number of citations of the paper that reports this interaction (PubMedID 8755540)
40

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		PITX1	POU1F1
Description		paired like homeodomain 1	POU class 1 homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity
	Biological Process	Skeletal System Development Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Determination Of Adult Lifespan Cell Differentiation B Cell Differentiation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Multicellular Organism Growth Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Somatotropin Secreting Cell Development
Pathways
Drugs
Diseases		Congenital clubfoot; Congenital talipes equinovarus	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 30529582 24836286 23263487) Colorectal cancer or advanced adenoma ( 30510241) Height ( 20881960 25429064 23563607 31562340 18391951) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)	Menarche (age at onset) ( 25231870) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		27 interacting genes: ALG13 C1orf94 CDX4 DVL3 EGR1 FOXO1 GOLGA2 HGS IPO13 LZTS2 MAGED1 MGAT5B NEUROD1 NR5A1 PLSCR1 POU1F1 PRR20A RBPMS RFX6 RHOXF2 RNF31 SMARCA2 SPAG8 TRAPPC2 TRIM23 UPF2 ZBTB32	12 interacting genes: CREBBP ETS1 GATA2 JUN NCOR1 NR1I2 NR1I3 NR3C1 PITX1 PPARA PPARG VDR
Entrez ID		5307	5449
HPRD ID		03688	01409
Ensembl ID		ENSG00000069011	ENSG00000064835
Uniprot IDs		P78337 X5D9A5	P28069
PDB IDs			5WC9
Enriched GO Terms of Interacting Partners?
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