PITX1 and SPAG8

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		PITX1	SPAG8
Description		paired like homeodomain 1	sperm associated antigen 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm	Acrosomal Vesicle Nucleus Cytoplasm Spindle Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Molecular_function Protein Binding Microtubule Binding
	Biological Process	Skeletal System Development Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development	Cell Cycle Spermatogenesis Single Fertilization Biological_process Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Congenital clubfoot; Congenital talipes equinovarus
GWAS		Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 30529582 24836286 23263487) Colorectal cancer or advanced adenoma ( 30510241) Height ( 20881960 25429064 23563607 31562340 18391951) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)	Blood protein levels ( 28240269)
Interacting Genes		27 interacting genes: ALG13 C1orf94 CDX4 DVL3 EGR1 FOXO1 GOLGA2 HGS IPO13 LZTS2 MAGED1 MGAT5B NEUROD1 NR5A1 PLSCR1 POU1F1 PRR20A RBPMS RFX6 RHOXF2 RNF31 SMARCA2 SPAG8 TRAPPC2 TRIM23 UPF2 ZBTB32	16 interacting genes: CARM1 CSTF2 DTX2 JMJD4 KDM3B KLHL32 NEDD4L NSD3 PITX1 PRMT1 PRMT2 PRMT5 RAN SIGMAR1 SNRPC UBQLN4
Entrez ID		5307	26206
HPRD ID		03688	12039
Ensembl ID		ENSG00000069011	ENSG00000137098
Uniprot IDs		P78337 X5D9A5	A0A140VJV0 Q99932
PDB IDs
Enriched GO Terms of Interacting Partners?
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