SERPINF2 and TGM2

Number of citations of the paper that reports this interaction (PubMedID 10958788)
9

Data Source:
HPRD (in vitro)

		SERPINF2	TGM2
Description		serpin family F member 2	transglutaminase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Cell Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Intrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Blood Vessel Diameter By Renin-angiotensin Platelet Degranulation Acute-phase Response Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Blood Vessel Remodeling Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation
Pathways		Platelet degranulation Dissolution of Fibrin Clot
Drugs		Ocriplasmin Copper	Guanosine-5'-Diphosphate
Diseases		Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		Blood protein levels ( 29875488) Calcium levels ( 24068962 20705733) Serum albumin level ( 23022100 29403010) Urate levels ( 31578528)
Interacting Genes		17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	59 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		5345	7052
HPRD ID		02029	01825
Ensembl ID		ENSG00000167711	ENSG00000198959
Uniprot IDs		P08697	B4DIT7 B4DTN7 P21980 V9HWG3
PDB IDs			1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P
Enriched GO Terms of Interacting Partners?
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