TGM2 and GCGR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		TGM2	GCGR
Description		transglutaminase 2	glucagon receptor
Image
GO Annotations	Cellular Component	Cell Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Intrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding	Glucagon Receptor Activity Guanyl-nucleotide Exchange Factor Activity G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Blood Vessel Remodeling Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	Generation Of Precursor Metabolites And Energy Exocytosis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Regulation Of Blood Pressure Hormone-mediated Signaling Pathway Glucose Homeostasis Response To Starvation Regulation Of Glycogen Metabolic Process Cellular Response To Glucagon Stimulus
Pathways
Drugs		Guanosine-5'-Diphosphate	Glucagon recombinant
Diseases
GWAS
Interacting Genes		59 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B	4 interacting genes: GCG GNAS TGM2 TP63
Entrez ID		7052	2642
HPRD ID		01825	00678
Ensembl ID		ENSG00000198959	ENSG00000215644
Uniprot IDs		B4DIT7 B4DTN7 P21980 V9HWG3	P47871
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P	2A83 3CZF 4ERS 4L6R 4LF3 5EE7 5XEZ
Enriched GO Terms of Interacting Partners?
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