TGM2 and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 10100610)
18

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		TGM2	KPNA4
Description		transglutaminase 2	karyopherin subunit alpha 4
Image
GO Annotations	Cellular Component	Cell Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Intrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Nuclear Pore Nucleoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Blood Vessel Remodeling Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Response To Hydrogen Peroxide
Pathways			ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS			Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		59 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B	20 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 GTF2IRD1 HIF1A HNRNPC KPNB1 MAT2B NTRK3 PLAA RAC1 RCC1 RECQL TGM2 TP53 WT1
Entrez ID		7052	3840
HPRD ID		01825	04275
Ensembl ID		ENSG00000198959	ENSG00000186432
Uniprot IDs		B4DIT7 B4DTN7 P21980 V9HWG3	O00629
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB
Enriched GO Terms of Interacting Partners?
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