SERPINF2 and CFD

Number of citations of the paper that reports this interaction (PubMedID 12080056)
4

Data Source:
HPRD (in vitro)

		SERPINF2	CFD
Description		serpin family F member 2	complement factor D
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Regulation Of Blood Vessel Diameter By Renin-angiotensin Platelet Degranulation Acute-phase Response Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Platelet Degranulation Proteolysis Complement Activation Complement Activation, Alternative Pathway Notch Signaling Pathway Neutrophil Degranulation
Pathways		Platelet degranulation Dissolution of Fibrin Clot	Platelet degranulation Alternative complement activation Neutrophil degranulation
Drugs		Ocriplasmin Copper	2-Aminobenzyl alcohol 3,4-Dichloroisocoumarin
Diseases		Alpha-2-plasmin inhibitor (a2-PI) deficiency	Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS		Blood protein levels ( 29875488) Calcium levels ( 24068962 20705733) Serum albumin level ( 23022100 29403010) Urate levels ( 31578528)
Interacting Genes		17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	2 interacting genes: HDHD2 SERPINF2
Entrez ID		5345	1675
HPRD ID		02029	00600
Ensembl ID		ENSG00000167711	ENSG00000197766
Uniprot IDs		P08697	A6XNE2 K7ERG9 P00746
PDB IDs			1BIO 1DFP 1DIC 1DST 1DSU 1FDP 1HFD 2XW9 2XWA 2XWB 4CBN 4CBO 4D9R 5FBE 5FBI 5FCK 5MT0 5MT4 5NAR 5NAT 5NAW 5NB6 5NB7 5NBA 5TCA 5TCC 6FTY 6FTZ 6FUG 6FUH 6FUI 6FUJ 6FUT 6QMR 6QMT
Enriched GO Terms of Interacting Partners?
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