SPAG8 and PRMT2

Number of citations of the paper that reports this interaction (PubMedID 23455924)
38

Data Source:
BioGRID (two hybrid)

		SPAG8	PRMT2
Description		sperm associated antigen 8	protein arginine methyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Spindle Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Molecular_function Protein Binding Microtubule Binding	Transcription Coactivator Activity Protein Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Estrogen Receptor Binding Progesterone Receptor Binding Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Protein Homodimerization Activity Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Thyroid Hormone Receptor Binding Androgen Receptor Binding
	Biological Process	Cell Cycle Spermatogenesis Single Fertilization Biological_process Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Protein Methylation Signal Transduction Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of NF-kappaB Transcription Factor Activity Histone Arginine Methylation Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Developmental Cell Growth Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Diverticular disease ( 30177863)
Interacting Genes		16 interacting genes: CARM1 CSTF2 DTX2 JMJD4 KDM3B KLHL32 NEDD4L NSD3 PITX1 PRMT1 PRMT2 PRMT5 RAN SIGMAR1 SNRPC UBQLN4	23 interacting genes: BAG6 CBLB CHEK2 CPSF7 DMRTB1 ESR1 ESR2 FIP1L1 HNRNPA1 HNRNPUL1 NCOA1 NCOA6 PGR PRRC2A PSMB3 RB1 RBM12 RIPK2 RXRA SPAG8 THRB WASL ZNF341
Entrez ID		26206	3275
HPRD ID		12039	09060
Ensembl ID		ENSG00000137098	ENSG00000160310
Uniprot IDs		A0A140VJV0 Q99932	A0A0S2Z3N3 P55345
PDB IDs			1X2P
Enriched GO Terms of Interacting Partners?
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