ABCB1 and HAX1

Number of citations of the paper that reports this interaction (PubMedID 15159385)
24

Data Source:
HPRD (in vivo, two hybrid)

		ABCB1	HAX1
Description		ATP binding cassette subfamily B member 1	HCLS1 associated protein X-1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome External Side Of Apical Plasma Membrane	P-body Nuclear Envelope Transcription Factor Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Sarcoplasmic Reticulum Lamellipodium Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Transporter Activity Protein Binding ATP Binding Xenobiotic Transmembrane Transporting ATPase Activity Efflux Transmembrane Transporter Activity ATPase Activity Ubiquitin Protein Ligase Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity Phosphatidylcholine-translocating ATPase Activity Phosphatidylethanolamine-translocating ATPase Activity Ceramide-translocating ATPase Activity	Protein Binding Interleukin-1 Binding Protein N-terminus Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Response To Drug Phospholipid Translocation Regulation Of Response To Osmotic Stress Transmembrane Transport Transepithelial Transport Stem Cell Proliferation Ceramide Translocation Export Across Plasma Membrane Positive Regulation Of Anion Channel Activity Drug Transport Across Blood-brain Barrier Regulation Of Chloride Transport	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Abacavir transmembrane transport ABC-family proteins mediated transport
Drugs		ATP Roxithromycin Voacamine Elacridar Tesmilifene FM-VP4 Miltefosine
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Bone mineral density (spine) and age at menarche ( 26312577) Gallbladder cancer ( 28274756) Neurological blood protein biomarker levels ( 31320639)	Bipolar disorder ( 31043756) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010)
Interacting Genes		11 interacting genes: BCCIP CAV1 CD4 HAX1 LNX1 MAPKAP1 MAPRE1 NEDD4 PIM1 PSMB8 RNF2	26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL UBAP2L YWHAQ ZNF420 ZNRD1
Entrez ID		5243	10456
HPRD ID		01370	12075
Ensembl ID		ENSG00000085563	ENSG00000143575
Uniprot IDs		A4D1D2 P08183	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs		6C0V 6FN1 6FN4 6QEX
Enriched GO Terms of Interacting Partners?
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