Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
ABCB1 and NEDD4
Number of citations of the paper that reports this interaction (PubMedID
26006083
)
5
Data Source:
BioGRID
(enzymatic study)
ABCB1
NEDD4
Description
ATP binding cassette subfamily B member 1
NEDD4 E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Plasma Membrane
Cell Surface
Membrane
Integral Component Of Membrane
Apical Plasma Membrane
Extracellular Exosome
External Side Of Apical Plasma Membrane
Ubiquitin Ligase Complex
Chromatin
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Cortex
Apicolateral Plasma Membrane
Dendritic Spine
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Cytosol
Molecular Function
Transporter Activity
Protein Binding
ATP Binding
Xenobiotic Transmembrane Transporting ATPase Activity
Efflux Transmembrane Transporter Activity
ATPase Activity
Ubiquitin Protein Ligase Binding
ATPase Activity, Coupled To Transmembrane Movement Of Substances
Xenobiotic Transmembrane Transporter Activity
Phosphatidylcholine-translocating ATPase Activity
Phosphatidylethanolamine-translocating ATPase Activity
Ceramide-translocating ATPase Activity
Protein Binding
Sodium Channel Inhibitor Activity
Enzyme Binding
Protein Domain Specific Binding
Beta-2 Adrenergic Receptor Binding
Ionotropic Glutamate Receptor Binding
Ubiquitin Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase Binding
Proline-rich Region Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Response To Drug
Phospholipid Translocation
Regulation Of Response To Osmotic Stress
Transmembrane Transport
Transepithelial Transport
Stem Cell Proliferation
Ceramide Translocation
Export Across Plasma Membrane
Positive Regulation Of Anion Channel Activity
Drug Transport Across Blood-brain Barrier
Regulation Of Chloride Transport
Protein Polyubiquitination
Adaptive Immune Response
Outflow Tract Morphogenesis
Endocardial Cushion Development
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Targeting To Lysosome
Lysosomal Transport
Neuromuscular Junction Development
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Macroautophagy
Protein Ubiquitination
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Receptor Internalization
Receptor Catabolic Process
Cellular Response To UV
Regulation Of Ion Transmembrane Transport
T Cell Activation
Regulation Of Membrane Potential
Glucocorticoid Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Development Involved In Symbiotic Interaction
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Nucleocytoplasmic Transport
Blood Vessel Morphogenesis
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Progesterone Receptor Signaling Pathway
Response To Calcium Ion
Protein K63-linked Ubiquitination
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Abacavir transmembrane transport
ABC-family proteins mediated transport
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
ATP
Roxithromycin
Voacamine
Elacridar
Tesmilifene
FM-VP4
Miltefosine
Diseases
GWAS
Bone mineral density (spine) and age at menarche (
26312577
)
Gallbladder cancer (
28274756
)
Neurological blood protein biomarker levels (
31320639
)
Brain connectivity (
23471985
)
Chronic lymphocytic leukemia (
28165464
24292274
)
Dupuytren's disease (
28886342
)
Hip circumference adjusted for BMI (
28552196
)
Intraocular pressure (
29617998
)
Joint mobility (Beighton score) (
27182965
)
Keloid (
20711176
)
Stroke (
29531354
)
Interacting Genes
11 interacting genes:
BCCIP
CAV1
CD4
HAX1
LNX1
MAPKAP1
MAPRE1
NEDD4
PIM1
PSMB8
RNF2
231 interacting genes:
ABCB1
ABL1
ABL2
ADRB2
AKT3
AMOT
AMOTL1
AMPD2
ANKRD13D
ANXA13
AP1G2
ARID1A
ASPSCR1
AURKC
BAIAP2
BMPR1A
BRCA2
CAD
CALCOCO1
CAMK1D
CAMK4
CAMKK2
CASP1
CASP3
CASP6
CASP7
CBLB
CCNH
CDC25C
CDK5
CDK5R1
CLIC2
CLK3
CPSF1
CPSF6
CUEDC1
DAZAP2
DCUN1D1
DDX3X
DDX54
DHX30
DIAPH1
DVL1
DYRK4
EBAG9
EGFR
EPHA5
EPRS1
EPS15
ERBB3
ERBB4
ERMN
ERRFI1
FES
FGF12
FGF21
FGFR1
FGFR2
FKBP3
FLT1
FLT4
FYN
GABARAP
GABARAPL1
GABARAPL2
GBA
GRB10
GRIN2A
GRK4
GRK7
H3-3A
HGS
HMCES
HNRNPK
HNRNPL
HNRNPU
HNRNPUL1
IFITM3
IGF1R
IRS1
IRS2
JHY
JUN
KCNAB1
KCNAB2
KCNJ16
KIFC3
LAPTM5
LATS1
LITAF
LUC7L2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K2
MAP3K3
MAP3K5
MAP4K5
MAPKAPK3
MARK2
MARK4
MLANA
MOB3A
MRPL19
MTMR4
MYCN
N4BP2
N4BP3
NDFIP1
NDFIP2
NFE2
NHP2
NSRP1
NUDT21
NUMB
PARP16
PAX7
PDGFRB
PIP5K1A
PIP5K1C
PKN2
PLK1
PLK2
PMEPA1
POLR2A
POLR2B
POLR2C
POLR2E
POLR2M
POLR3A
PRKG2
PRKX
PRPF8
PRR16
PRRG1
PRRG2
PSMD4
PYM1
RAC1
RAD51AP1
RAF1
RANBP10
RAP2A
RAPGEF2
RAPGEF6
RASGEF1A
RASL11B
RBCK1
RET
RFT1
RNF11
RNF7
RPAP2
RPAP3
RPL18A
RPS3A
RPS6KA3
RPS6KA4
RPS6KB1
RUNX1
RUVBL1
SAAL1
SAMSN1
SAV1
SCAMP3
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEPTIN9
SERTAD1
SFTPC
SGK1
SGK2
SH3KBP1
SHTN1
SIVA1
SLC23A2
SLC6A3
SMAD1
SMAD3
SMAD5
SMARCC1
SMO
SNCA
SP140L
SPANXN3
SPRY2
SRC
SRMS
SRSF7
STK24
STK25
STK26
STK31
STK4
SULF1
SYK
SYT1
TAF1B
TBC1D7
TBK1
TCEANC
TCP11L1
TEAD2
THOC1
THRAP3
TNIK
TOM1
TOM1L2
TP73
TRIM44
TRIM52
TRPV6
TSTA3
TTYH2
UBAP2L
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2L3
UBE2M
UBOX5
URI1
WBP1
WBP2
WEE1
YES1
YOD1
Entrez ID
5243
4734
HPRD ID
01370
03786
Ensembl ID
ENSG00000085563
ENSG00000069869
Uniprot IDs
A4D1D2
P08183
P46934
PDB IDs
6C0V
6FN1
6FN4
6QEX
2KPZ
2KQ0
2M3O
2XBB
2XBF
3B7Y
4BBN
4BE8
4N7F
4N7H
5AHT
5C7J
5C91
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?