HAX1 and DGKD

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HAX1	DGKD
Description		HCLS1 associated protein X-1	diacylglycerol kinase delta
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nuclear Envelope Transcription Factor Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Sarcoplasmic Reticulum Lamellipodium Cytoplasmic Vesicle Nuclear Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Interleukin-1 Binding Protein N-terminus Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization	Endocytosis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Response To Organic Substance Protein Transport Second-messenger-mediated Signaling Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation
Pathways			Effects of PIP2 hydrolysis
Drugs			Phosphatidyl serine
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Bipolar disorder ( 31043756) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010)	Bilirubin levels ( 20639394) Calcium levels ( 24068962 29403010 20705733) Crohn's disease ( 22412388) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Plateletcrit ( 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30718926) Urinary calcium excretion ( 31993563)
Interacting Genes		26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL UBAP2L YWHAQ ZNF420 ZNRD1	7 interacting genes: DGKH HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14
Entrez ID		10456	8527
HPRD ID		12075	03492
Ensembl ID		ENSG00000143575	ENSG00000077044
Uniprot IDs		A0A0S2Z565 A0A0S2Z591 O00165	A0A024R495 Q16760
PDB IDs			1R79 3BQ7
Enriched GO Terms of Interacting Partners?
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