ABCB1 and MAPRE1

Number of citations of the paper that reports this interaction (PubMedID 24552808)
15

Data Source:
BioGRID (two hybrid)

		ABCB1	MAPRE1
Description		ATP binding cassette subfamily B member 1	microtubule associated protein RP/EB family member 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome External Side Of Apical Plasma Membrane	Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Microtubule Cytoplasmic Microtubule Focal Adhesion Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Spindle Midzone Mitotic Spindle Astral Microtubule End
	Molecular Function	Transporter Activity Protein Binding ATP Binding Xenobiotic Transmembrane Transporting ATPase Activity Efflux Transmembrane Transporter Activity ATPase Activity Ubiquitin Protein Ligase Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity Phosphatidylcholine-translocating ATPase Activity Phosphatidylethanolamine-translocating ATPase Activity Ceramide-translocating ATPase Activity	RNA Binding Protein Binding Microtubule Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Response To Drug Phospholipid Translocation Regulation Of Response To Osmotic Stress Transmembrane Transport Transepithelial Transport Stem Cell Proliferation Ceramide Translocation Export Across Plasma Membrane Positive Regulation Of Anion Channel Activity Drug Transport Across Blood-brain Barrier Regulation Of Chloride Transport	G2/M Transition Of Mitotic Cell Cycle Microtubule Bundle Formation Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Migration Positive Regulation Of Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end
Pathways		Abacavir transmembrane transport ABC-family proteins mediated transport	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		ATP Roxithromycin Voacamine Elacridar Tesmilifene FM-VP4 Miltefosine
Diseases
GWAS		Bone mineral density (spine) and age at menarche ( 26312577) Gallbladder cancer ( 28274756) Neurological blood protein biomarker levels ( 31320639)	Iron status biomarkers (transferrin saturation) ( 28334935) Polycystic ovary syndrome ( 30566500) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		11 interacting genes: BCCIP CAV1 CD4 HAX1 LNX1 MAPKAP1 MAPRE1 NEDD4 PIM1 PSMB8 RNF2	44 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 CASK CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL21 LMO2 LRP1 MACF1 MAPRE2 MAPRE3 NAV1 NUPR1 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SRC SRPK2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB
Entrez ID		5243	22919
HPRD ID		01370	04379
Ensembl ID		ENSG00000085563	ENSG00000101367
Uniprot IDs		A4D1D2 P08183	Q15691
PDB IDs		6C0V 6FN1 6FN4 6QEX	1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ
Enriched GO Terms of Interacting Partners?
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