PFDN1 and NDC80

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		PFDN1	NDC80
Description		prefoldin subunit 1	NDC80 kinetochore complex component
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GO Annotations	Cellular Component	Prefoldin Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex
	Molecular Function	DNA-binding Transcription Factor Activity Protein Binding Protein Binding Involved In Protein Folding Unfolded Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Folding	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)	Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		53 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	46 interacting genes: AMOTL2 ATF4 ATP5PO AURKA AURKB BLOC1S6 CALCOCO1 CCHCR1 CCNH CCNK CENPH CKAP5 HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 WASHC3 ZWINT
Entrez ID		5201	10403
HPRD ID		05357	06277
Ensembl ID		ENSG00000113068	ENSG00000080986
Uniprot IDs		O60925	A8K031 O14777
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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