NDC80 and ATP5PO

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NDC80	ATP5PO
Description		NDC80 kinetochore complex component	ATP synthase peripheral stalk subunit OSCP
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Drug Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore	ATP Biosynthetic Process Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport Proton Transmembrane Transport
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs			Artenimol
Diseases
GWAS		Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		46 interacting genes: AMOTL2 ATF4 ATP5PO AURKA AURKB BLOC1S6 CALCOCO1 CCHCR1 CCNH CCNK CENPH CKAP5 HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 WASHC3 ZWINT	15 interacting genes: APP CCDC136 CEP70 HMBOX1 KRT13 KRT15 MIPOL1 NDC80 NME6 NT5C2 PNMA1 TFIP11 TRIP6 USHBP1 ZBTB14
Entrez ID		10403	539
HPRD ID		06277	02899
Ensembl ID		ENSG00000080986	ENSG00000241837
Uniprot IDs		A8K031 O14777	P48047
PDB IDs		2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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