NDC80 and NDE1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		NDC80	NDE1
Description		NDC80 kinetochore complex component	nudE neurodevelopment protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex	Kinetochore Condensed Chromosome Kinetochore Cell Centrosome Cytosol Kinesin Complex Microtubule Membrane Spindle Pole Centrosome Cleavage Furrow Synapse
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Microtubule Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Neuron Migration Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Neuroblast Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Migration Cerebral Cortex Development Vesicle Transport Along Microtubule Centrosome Duplication Cell Division Establishment Of Chromosome Localization Centrosome Localization Ciliary Basal Body-plasma Membrane Docking Regulation Of Microtubule Motor Activity
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Multiple system atrophy (pathologically confirmed) ( 27629089) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		46 interacting genes: AMOTL2 ATF4 ATP5PO AURKA AURKB BLOC1S6 CALCOCO1 CCHCR1 CCNH CCNK CENPH CKAP5 HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 WASHC3 ZWINT	27 interacting genes: AR ARNT2 CDK1 DISC1 FAM9B FBXO7 GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 PAFAH1B1 REL TFIP11 TRIM27 TSPOAP1 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398
Entrez ID		10403	54820
HPRD ID		06277	14815
Ensembl ID		ENSG00000080986	ENSG00000072864
Uniprot IDs		A8K031 O14777	Q9NXR1 X5DP35 X5DR54
PDB IDs		2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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