CXCL13 and CXCR5

Number of citations of the paper that reports this interaction (PubMedID 9486651)
183

Data Source:
HPRD (in vivo, in vitro)

		CXCL13	CXCR5
Description		C-X-C motif chemokine ligand 13	C-X-C motif chemokine receptor 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell	Cell Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Chemokine Activity Heparin Binding Fibroblast Growth Factor Binding CXCR5 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding	G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding
	Biological Process	Germinal Center Formation Lymphocyte Chemotaxis Across High Endothelial Venule Chronic Inflammatory Response Regulation Of Humoral Immune Response Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Leukocyte Chemotaxis Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Chemotaxis Endothelial Cell Chemotaxis To Fibroblast Growth Factor Defense Response To Bacterium Regulation Of Angiogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Activation Of GTPase Activity Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Cytokinesis B Cell Activation Lymph Node Development Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Diffusing capacity of carbon monoxide ( 30694715) Tonsillectomy ( 27182965 28928442) Waist circumference adjusted for body mass index ( 28552196)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Follicular lymphoma ( 25279986) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 24076602 21833088) Primary biliary cholangitis ( 28425483 21399635 26394269) Rheumatoid arthritis ( 30423114 24390342) SjÃ¶gren's syndrome ( 24097067) Trunk fat mass ( 28552196) Vitiligo ( 22951725)
Interacting Genes		8 interacting genes: ACKR4 CCL19 CCL21 CCR10 CXCR3 CXCR5 EEF1G FGF2	1 interacting genes: CXCL13
Entrez ID		10563	643
HPRD ID		05513	03367
Ensembl ID		ENSG00000156234	ENSG00000160683
Uniprot IDs		O43927 Q53X90	A0N0R2 A8K647 P32302 Q2YD84
PDB IDs		4ZAI 5CBA 5CBE
Enriched GO Terms of Interacting Partners?
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