ZBTB7A and SP4

Number of citations of the paper that reports this interaction (PubMedID 12004059)
31

Data Source:
HPRD (in vitro)

		ZBTB7A	SP4
Description		zinc finger and BTB domain containing 7A	Sp4 transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm NuRD Complex Site Of Double-strand Break DNA-dependent Protein Kinase Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding SMAD Binding Metal Ion Binding Androgen Receptor Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Glycolytic Process Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus B Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Regulation Of Apoptotic Process Erythrocyte Maturation Fat Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Androgen Receptor Signaling Pathway Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Transcription Regulatory Region DNA Binding	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleic Acid-templated Transcription
Pathways
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Pulse pressure ( 30578418) Reaction time ( 29844566) Red blood cell count ( 27863252)	Acute lymphoblastic leukemia (childhood) ( 29348612) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Bipolar disorder ( 31043756) General cognitive ability ( 29844566) Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multisite chronic pain ( 31194737) Schizophrenia ( 30285260) Temporomandibular joint disorder ( 28081371)
Interacting Genes		19 interacting genes: AR BCL6 CRBN HOMEZ KHDRBS1 MBD3 NCOR1 NCOR2 PRKDC RELA SMAD4 SP1 SP3 SP4 UBE2I XRCC5 XRCC6 ZBTB48 ZMYND8	16 interacting genes: - ADAM15 ATXN7L1 BANP CIB3 COL8A1 E2F1 FOXP2 LMO3 NKX3-1 NRF1 POU2F1 PRR20A SERF2 SP1 ZBTB7A
Entrez ID		51341	6671
HPRD ID		10433	02764
Ensembl ID		ENSG00000178951	ENSG00000105866
Uniprot IDs		O95365	A0A3B3IRW4 Q02446 Q32M51
PDB IDs		2IF5 2NN2
Enriched GO Terms of Interacting Partners?
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