CRBN and SALL3

Number of citations of the paper that reports this interaction (PubMedID 30385546)
17

Data Source:
BioGRID (pull down)

		CRBN	SALL3
Description		cereblon	spalt like transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleus
	Molecular Function	Protein Binding Ion Channel Binding Metal Ion Binding	DNA Binding DNA-binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Negative Regulation Of Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription, DNA-templated Olfactory Bulb Interneuron Development Forelimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Smoothened Signaling Pathway
Pathways
Drugs		Lenalidomide Thalidomide Pomalidomide
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Attention function in attention deficit hyperactive disorder ( 26174813) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Rheumatoid arthritis ( 18668548) Smoking initiation (ever regular vs never regular) ( 31089300) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		33 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	1 interacting genes: CRBN
Entrez ID		51185	27164
HPRD ID		16750	05467
Ensembl ID		ENSG00000113851	ENSG00000256463
Uniprot IDs		Q96SW2	A0A384MEH2 A9JR48 Q9BXA9
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G
Enriched GO Terms of Interacting Partners?
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