CRBN and IKZF3

Number of citations of the paper that reports this interaction (PubMedID 30042095)
7

Data Source:
BioGRID (enzymatic study)

		CRBN	IKZF3
Description		cereblon	IKAROS family zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Ion Channel Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Negative Regulation Of Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription By RNA Polymerase II Mesoderm Development Response To Bacterium Regulation Of B Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Regulation Of B Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs		Lenalidomide Thalidomide Pomalidomide
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)	Acute lymphoblastic leukemia (childhood) ( 29348612) Asthma ( 31619474 28461288) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic march ( 26542096) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 28067908 21102463) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte counts ( 29403010 27863252) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 30343302) Primary biliary cholangitis ( 19458352 23000144 20639880 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 27399966 26502338) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Type 1 diabetes ( 25751624) Ulcerative colitis ( 28067908 20228799 21297633)
Interacting Genes		33 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	93 interacting genes: ABLIM3 AKAP10 AKAP9 AQP1 ARMC7 ARNT2 ATP6V0D1 ATPAF2 BCAS2 BCL2L1 C1orf109 CABP4 CABP5 CDKN1A CDKN2D CHCHD2 CHD3 CRBN CRK CRYBA4 DGCR6 EFHC1 EMC2 EXOC8 EXOSC5 FANCG FANCL FARS2 FBF1 FHL3 GEM GOLGA2 GRAP2 GRB2 HNRNPF HNRNPLL HRAS IKZF1 IKZF4 IKZF5 ING5 KAT5 KRT19 LDOC1 LGALS14 LMO1 LMO2 MAGOHB MCM7 MORN3 MRPL28 MRPL53 NATD1 NEK6 NTAQ1 OAZ3 OSGIN1 PCID2 PFDN5 PIK3R1 PIK3R2 PIN1 POLM POLR1C PPP1R16B PRDM1 PRKAA1 PRKAB2 PSMA1 PSMF1 RAD51D RBBP8 RCOR3 RHOA RNF6 RUNX1 SMARCB1 SPG21 STAMBPL1 STK16 STK26 STX11 SUMO1 TBC1D22B TCAF1 TEKT4 TLE5 TRAPPC6A TRIM42 TSSK3 TSTD2 UBE2I ZGPAT
Entrez ID		51185	22806
HPRD ID		16750	05869
Ensembl ID		ENSG00000113851	ENSG00000161405
Uniprot IDs		Q96SW2	Q9UKT9
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G
Enriched GO Terms of Interacting Partners?
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