CRBN and ZFP91

Number of citations of the paper that reports this interaction (PubMedID 30385546)
17

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CRBN	ZFP91
Description		cereblon	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleoplasm Cytosol
	Molecular Function	Protein Binding Ion Channel Binding Metal Ion Binding	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Metal Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Negative Regulation Of Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Activation Of NF-kappaB-inducing Kinase Activity Protein K63-linked Ubiquitination
Pathways
Drugs		Lenalidomide Thalidomide Pomalidomide
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)	Chronotype ( 30696823) Medication use (calcium channel blockers) ( 31015401) Morning person ( 30696823) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		33 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	4 interacting genes: CDKN2A CRBN MAP3K14 SRPK2
Entrez ID		51185	80829
HPRD ID		16750	11700
Ensembl ID		ENSG00000113851	ENSG00000186660
Uniprot IDs		Q96SW2	A0A024R4Z1 A0A024R4Z4 Q96JP5
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G	2M9A
Enriched GO Terms of Interacting Partners?
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