CRBN and SALL4

Number of citations of the paper that reports this interaction (PubMedID 30385546)
17

Data Source:
BioGRID (pull down, enzymatic study)

		CRBN	SALL4
Description		cereblon	spalt like transcription factor 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Heterochromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ion Channel Binding Metal Ion Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Negative Regulation Of Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Inner Cell Mass Cell Proliferation Neural Tube Closure Ventricular Septum Development Regulation Of Transcription, DNA-templated Embryonic Limb Morphogenesis Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II
Pathways			POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs		Lenalidomide Thalidomide Pomalidomide
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)	Duane-radial ray syndrome and IVIC syndrome; Okihiro syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)	Male infertility ( 19478329) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		33 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	2 interacting genes: CRBN RBBP4
Entrez ID		51185	57167
HPRD ID		16750	08458
Ensembl ID		ENSG00000113851	ENSG00000101115
Uniprot IDs		Q96SW2	Q9UJQ4
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G	5XWR
Enriched GO Terms of Interacting Partners?
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