IKZF3 and STK16

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		IKZF3	STK16
Description		IKAROS family zinc finger 3	serine/threonine kinase 16
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Cytoplasm Golgi-associated Vesicle Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Promoter-specific Chromatin Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Mesoderm Development Response To Bacterium Regulation Of B Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Regulation Of B Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 29348612) Asthma ( 31619474 28461288) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic march ( 26542096) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 28067908 21102463) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte counts ( 29403010 27863252) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 30343302) Primary biliary cholangitis ( 19458352 23000144 20639880 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 27399966 26502338) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Type 1 diabetes ( 25751624) Ulcerative colitis ( 28067908 20228799 21297633)
Interacting Genes		93 interacting genes: ABLIM3 AKAP10 AKAP9 AQP1 ARMC7 ARNT2 ATP6V0D1 ATPAF2 BCAS2 BCL2L1 C1orf109 CABP4 CABP5 CDKN1A CDKN2D CHCHD2 CHD3 CRBN CRK CRYBA4 DGCR6 EFHC1 EMC2 EXOC8 EXOSC5 FANCG FANCL FARS2 FBF1 FHL3 GEM GOLGA2 GRAP2 GRB2 HNRNPF HNRNPLL HRAS IKZF1 IKZF4 IKZF5 ING5 KAT5 KRT19 LDOC1 LGALS14 LMO1 LMO2 MAGOHB MCM7 MORN3 MRPL28 MRPL53 NATD1 NEK6 NTAQ1 OAZ3 OSGIN1 PCID2 PFDN5 PIK3R1 PIK3R2 PIN1 POLM POLR1C PPP1R16B PRDM1 PRKAA1 PRKAB2 PSMA1 PSMF1 RAD51D RBBP8 RCOR3 RHOA RNF6 RUNX1 SMARCB1 SPG21 STAMBPL1 STK16 STK26 STX11 SUMO1 TBC1D22B TCAF1 TEKT4 TLE5 TRAPPC6A TRIM42 TSSK3 TSTD2 UBE2I ZGPAT	47 interacting genes: ADAMTSL4 CALCOCO2 CCDC33 CRX CSNK2B DNAJA3 DRG1 EFEMP2 EFHC2 ELK1 FLACC1 IKZF3 INCA1 KCTD14 KCTD17 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-1 KRTAP26-1 MBP MEOX2 MGAT5B MIIP MTUS2 NAGK NIF3L1 NOTCH2NLA PCSK5 PLSCR1 PLSCR3 REL RFX6 RPIA SAXO1 SKIL SPRY2 TCF12 TCF4 TLE5 TNFAIP1 TRAF3IP2 TRIM27 TRIM42 TRIP6
Entrez ID		22806	8576
HPRD ID		05869	05281
Ensembl ID		ENSG00000161405	ENSG00000115661
Uniprot IDs		Q9UKT9	B4DPS1 B8ZZI5 O75716
PDB IDs			2BUJ
Enriched GO Terms of Interacting Partners?
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