PCNA and YBX1

Number of citations of the paper that reports this interaction (PubMedID 9927044)
46

Data Source:
HPRD (in vivo, in vitro)

		PCNA	YBX1
Description		proliferating cell nuclear antigen	Y-box binding protein 1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nuclear Chromosome, Telomeric Region Chromatin Nucleus Nuclear Lamina Nucleoplasm Replication Fork Centrosome Nuclear Body Replisome Nuclear Replication Fork PCNA Complex Extracellular Exosome PCNA-p21 Complex	Extracellular Region Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex Messenger Ribonucleoprotein Complex Ribonucleoprotein Complex
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Chromatin Binding Damaged DNA Binding Protein Binding Protein C-terminus Binding Enzyme Binding Estrogen Receptor Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Histone Acetyltransferase Binding Identical Protein Binding Protein-containing Complex Binding DNA Polymerase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding MRNA Binding Protein Binding MiRNA Binding GTPase Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Leading Strand Elongation Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Heart Development Viral Process Protein Ubiquitination Translesion Synthesis Epithelial Cell Differentiation Replication Fork Processing Positive Regulation Of Deoxyribonuclease Activity Telomere Maintenance Via Semi-conservative Replication Response To Estradiol Nucleotide-excision Repair, DNA Incision Cellular Response To UV Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Estrous Cycle Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Response To Cadmium Ion Cellular Response To Hydrogen Peroxide Error-free Translesion Synthesis Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Liver Regeneration Positive Regulation Of DNA-directed DNA Polymerase Activity Response To L-glutamate Mitotic Telomere Maintenance Via Semi-conservative Replication	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Notch Signaling Pathway Epidermis Development Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Embryonic Morphogenesis RNA Transport TRNA Transport Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization Cellular Response To Interleukin-7 Protein Localization To Cytoplasmic Stress Granule MiRNA Transport Negative Regulation Of Cellular Senescence
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Transcription of E2F targets under negative control by DREAM complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand SUMOylation of DNA replication proteins Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription E3 ubiquitin ligases ubiquitinate target proteins	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Noncanonical activation of NOTCH3
Drugs		Liothyronine
Diseases
GWAS
Interacting Genes		132 interacting genes: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 CREBBP DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 ERRFI1 ESCO2 EXO1 FAN1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HLTF HUS1 HUWE1 IGF1R ING1 KCTD13 LDHA LIG1 LMNA MCL1 MGMT MLH1 MSH2 MSH3 MSH6 MUTYH MYBBP1A NSD2 NTHL1 PARP1 PARP10 PARPBP PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLK POLL POLM PPP1CA PRKDC PTMA RAD18 RAD9A RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RFWD3 RNF8 RPA1 SDE2 SEC23IP SHPRH SIVA1 SMARCAD1 SUB1 SUMO1 TCOF1 TDG TIRAP TMEM218 TPI1 TRAIP UBB UBE2A UBE2B UBE2D3 UHRF1 UNG USP1 USP2 USP4 WDR48 WRN WRNIP1 XPA XRCC1 XRCC5 XRCC6 YBX1 ZBTB1	43 interacting genes: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CASP8 CSNK2A1 CTCF FBXO33 FMR1 FUS GSK3B H1-2 HABP4 HLA-C HNRNPD HNRNPK IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 MYC MYCN NFYB PCBP2 PCNA PRPF40A PURA RBBP6 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 VEGFA
Entrez ID		5111	4904
HPRD ID		01456	01095
Ensembl ID		ENSG00000132646	ENSG00000065978
Uniprot IDs		P12004	P67809
PDB IDs		1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3JA9 3P87 3TBL 3VKX 3WGW 4D2G 4RJF 4ZTD 5E0T 5E0U 5E0V 5IY4 5MAV 5MLO 5MLW 5MOM 5YCO 5YD8 6CBI 6EHT 6FCM 6FCN 6GIS 6GWS 6HVO 6K3A 6QC0 6QCG	1H95 5YTS 5YTT 5YTV 5YTX 6A6L
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?