PCNA and ATAD5

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		PCNA	ATAD5
Description		proliferating cell nuclear antigen	ATPase family AAA domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nuclear Chromosome, Telomeric Region Chromatin Nucleus Nuclear Lamina Nucleoplasm Replication Fork Centrosome Nuclear Body Replisome Nuclear Replication Fork PCNA Complex Extracellular Exosome PCNA-p21 Complex	Nucleus Elg1 RFC-like Complex
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Chromatin Binding Damaged DNA Binding Protein Binding Protein C-terminus Binding Enzyme Binding Estrogen Receptor Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Histone Acetyltransferase Binding Identical Protein Binding Protein-containing Complex Binding DNA Polymerase Binding	DNA Binding Protein Binding ATP Binding DNA Clamp Unloader Activity
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Leading Strand Elongation Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Heart Development Viral Process Protein Ubiquitination Translesion Synthesis Epithelial Cell Differentiation Replication Fork Processing Positive Regulation Of Deoxyribonuclease Activity Telomere Maintenance Via Semi-conservative Replication Response To Estradiol Nucleotide-excision Repair, DNA Incision Cellular Response To UV Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Estrous Cycle Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Response To Cadmium Ion Cellular Response To Hydrogen Peroxide Error-free Translesion Synthesis Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Liver Regeneration Positive Regulation Of DNA-directed DNA Polymerase Activity Response To L-glutamate Mitotic Telomere Maintenance Via Semi-conservative Replication	Positive Regulation Of B Cell Proliferation Nuclear DNA Replication B Cell Proliferation Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Isotype Switching Positive Regulation Of DNA Replication Positive Regulation Of Isotype Switching To IgG Isotypes Nucleic Acid Phosphodiester Bond Hydrolysis DNA Clamp Unloading Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Transcription of E2F targets under negative control by DREAM complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand SUMOylation of DNA replication proteins Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Liothyronine
Diseases
GWAS			Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth weight ( 31043758) Body mass index ( 28892062) Breast cancer ( 25751625 29059683) Diastolic blood pressure ( 30224653) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 23563607 18391951) Hip circumference adjusted for BMI ( 25673412) Lung cancer in ever smokers ( 28604730) Mean platelet volume ( 27863252) Neutrophil percentage of white cells ( 27863252) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 28448500)
Interacting Genes		132 interacting genes: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 CREBBP DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 ERRFI1 ESCO2 EXO1 FAN1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HLTF HUS1 HUWE1 IGF1R ING1 KCTD13 LDHA LIG1 LMNA MCL1 MGMT MLH1 MSH2 MSH3 MSH6 MUTYH MYBBP1A NSD2 NTHL1 PARP1 PARP10 PARPBP PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLK POLL POLM PPP1CA PRKDC PTMA RAD18 RAD9A RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RFWD3 RNF8 RPA1 SDE2 SEC23IP SHPRH SIVA1 SMARCAD1 SUB1 SUMO1 TCOF1 TDG TIRAP TMEM218 TPI1 TRAIP UBB UBE2A UBE2B UBE2D3 UHRF1 UNG USP1 USP2 USP4 WDR48 WRN WRNIP1 XPA XRCC1 XRCC5 XRCC6 YBX1 ZBTB1	2 interacting genes: PCNA RAD9A
Entrez ID		5111	79915
HPRD ID		01456	07792
Ensembl ID		ENSG00000132646	ENSG00000176208
Uniprot IDs		P12004	Q96QE3
PDB IDs		1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3JA9 3P87 3TBL 3VKX 3WGW 4D2G 4RJF 4ZTD 5E0T 5E0U 5E0V 5IY4 5MAV 5MLO 5MLW 5MOM 5YCO 5YD8 6CBI 6EHT 6FCM 6FCN 6GIS 6GWS 6HVO 6K3A 6QC0 6QCG
Enriched GO Terms of Interacting Partners?
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