YBX1 and VEGFA

Number of citations of the paper that reports this interaction (PubMedID 16198352)
23

Data Source:
HPRD (in vitro)

		YBX1	VEGFA
Description		Y-box binding protein 1	vascular endothelial growth factor A
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex Messenger Ribonucleoprotein Complex Ribonucleoprotein Complex	Extracellular Region Extracellular Space Cytoplasm Adherens Junction Cell Surface Membrane Secretory Granule Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding MRNA Binding Protein Binding MiRNA Binding GTPase Binding	Fibronectin Binding Cytokine Activity Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 1 Binding Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Ligand Activity Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Notch Signaling Pathway Epidermis Development Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Embryonic Morphogenesis RNA Transport TRNA Transport Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization Cellular Response To Interleukin-7 Protein Localization To Cytoplasmic Stress Granule MiRNA Transport Negative Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovarian Follicle Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia In Utero Embryonic Development Kidney Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Receptor Internalization Platelet Degranulation Positive Regulation Of Leukocyte Migration Heart Morphogenesis Outflow Tract Morphogenesis Coronary Vein Morphogenesis Regulation Of Transcription By RNA Polymerase II Nervous System Development Mesoderm Development Lactation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nitric Oxide Mediated Signal Transduction Cytokine-mediated Signaling Pathway Monocyte Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Cell Migration Epithelial Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Post-embryonic Camera-type Eye Development Positive Regulation Of Protein Complex Assembly Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Tube Formation Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Lymph Vessel Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Eye Photoreceptor Cell Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Surfactant Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Camera-type Eye Morphogenesis Cardiac Muscle Fiber Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cellular Component Movement Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Primitive Erythrocyte Differentiation Mammary Gland Alveolus Development Positive Regulation Of Mast Cell Chemotaxis Cardiac Vascular Smooth Muscle Cell Development Coronary Artery Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Motor Neuron Migration Cellular Stress Response To Acid Chemical Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Adherens Junction Organization Positive Regulation Of Protein Kinase D Signaling Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Maintenance Of Permeability Of Blood-brain Barrier Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Noncanonical activation of NOTCH3	Platelet degranulation Regulation of gene expression by Hypoxia-inducible Factor Signaling by VEGF VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization Interleukin-4 and Interleukin-13 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs			Bevacizumab Minocycline Gliclazide Carvedilol Ranibizumab Pidolic Acid Tromethamine Vandetanib ABT-510 VEGF-AS Dalteparin Aflibercept Chondroitin sulfate
Diseases			Gastric cancer
GWAS			Adiponectin levels ( 22479202) Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636 21665990) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Chronic kidney disease ( 20383146) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Creatinine levels ( 31015462 29124443 29403010) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462 29124443 30604766) Fasting glucose change (short-term) ( 31263163) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) High density lipoprotein cholesterol levels ( 29403010) High light scatter reticulocyte percentage of red cells ( 27863252) Hyperthyroidism ( 30367059) Hyperuricemia ( 29124443) Hypothyroidism ( 27182965) Interleukin-10 levels ( 27989323) Interleukin-12p70 levels ( 27989323) Interleukin-13 levels ( 27989323) Interleukin-7 levels ( 27989323) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Plasma thyroid-stimulating hormone levels ( 28333968) Prostate-specific antigen levels ( 28139693) Red blood cell count ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Serum uric acid levels ( 30993211 29124443) Sexual dimorphism in anthropometric traits ( 23754948) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335) Triglyceride levels ( 28334899 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943) Type 2 diabetes ( 18372903 24509480 30054458 29358691 30297969) Urate levels ( 31578528 23263486) Urinary albumin-to-creatinine ratio ( 31630189) Vascular endothelial growth factor levels ( 26910538 27989323 31217265) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412 28448500) White blood cell count ( 27863252)
Interacting Genes		43 interacting genes: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CASP8 CSNK2A1 CTCF FBXO33 FMR1 FUS GSK3B H1-2 HABP4 HLA-C HNRNPD HNRNPK IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 MYC MYCN NFYB PCBP2 PCNA PRPF40A PURA RBBP6 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 VEGFA	32 interacting genes: ADAMTS1 AKT1 CCN2 CRYAB ELAVL1 EPHB2 FLT1 FN1 GPC1 HIF1A HNRNPD IGFBP7 KDR LYVE1 MDM2 NRP1 NRP2 PGF PRRG4 SEMA3F SP1 SP3 SPARC TFAP2A TNXB U2AF1 UBIAD1 VEGFB VPS35 VTN YBX1 YBX3
Entrez ID		4904	7422
HPRD ID		01095	01889
Ensembl ID		ENSG00000065978	ENSG00000112715
Uniprot IDs		P67809	A0A024RD33 A0A024RD37 A0A0Y0IMM4 A2A2V4 P15692
PDB IDs		1H95 5YTS 5YTT 5YTV 5YTX 6A6L	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS 4KZN 4QAF 4WPB 4ZFF 5DN2 5FV1 5FV2 5HHC 5HHD 5O4E 5T89 6BFT 6D3O
Enriched GO Terms of Interacting Partners?
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