SHANK1 and USP8

Number of citations of the paper that reports this interaction (PubMedID 29735556)
4

Data Source:
BioGRID (enzymatic study)

		SHANK1	USP8
Description		SH3 and multiple ankyrin repeat domains 1	ubiquitin specific peptidase 8
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GO Annotations	Cellular Component	Cell Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Cytoplasm Early Endosome Cytosol Postsynaptic Density Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane Dendritic Spine Glutamatergic Synapse
	Molecular Function	Protein Binding Protein C-terminus Binding SH3 Domain Binding Receptor Signaling Complex Scaffold Activity GKAP/Homer Scaffold Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Cytoskeletal Anchoring At Plasma Membrane Synapse Assembly Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Righting Reflex Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Mitotic Cytokinesis Ubiquitin-dependent Protein Catabolic Process Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cellular Response To Nerve Growth Factor Stimulus
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity
Drugs
Diseases
GWAS		Clozapine-induced cytotoxicity ( 25656473)	Ankylosing spondylitis ( 30946743) Heel bone mineral density ( 30598549)
Interacting Genes		18 interacting genes: ABCA1 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8	40 interacting genes: BACE1 BIRC6 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 EPS15 GRAP2 GRB2 H2AC20 H2BC21 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ
Entrez ID		50944	9101
HPRD ID		05413	04405
Ensembl ID		ENSG00000161681	ENSG00000138592
Uniprot IDs		H9KV90 Q9Y566	A0A024R5S4 A8K8N5 P40818
PDB IDs		6CPI	1WHB 2A9U 2GFO 2GWF 3N3K 6F09
Enriched GO Terms of Interacting Partners?
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