USP8 and CHMP1A

Number of citations of the paper that reports this interaction (PubMedID 19302785)
8

Data Source:
BioGRID (pull down)

		USP8	CHMP1A
Description		ubiquitin specific peptidase 8	charged multivesicular body protein 1A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Postsynaptic Density Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane Dendritic Spine Glutamatergic Synapse	Condensed Nuclear Chromosome ESCRT III Complex Cell Early Endosome Multivesicular Body Microtubule Organizing Center Endomembrane System Nuclear Matrix Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding Cadherin Binding	Protein Binding Metallopeptidase Activity Zinc Ion Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Mitotic Cytokinesis Ubiquitin-dependent Protein Catabolic Process Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cellular Response To Nerve Growth Factor Stimulus	Proteolysis Nucleus Organization Mitotic Chromosome Condensation Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Vesicle-mediated Transport Gene Silencing Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Late Endosome To Vacuole Transport Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Division Midbody Abscission Regulation Of Mitotic Spindle Assembly ESCRT III Complex Disassembly
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	HCMV Late Events
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Heel bone mineral density ( 30598549)	Diastolic blood pressure ( 30578418) Estimated glomerular filtration rate ( 31152163) Low tan response ( 29739929) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Plasma homocysteine levels ( 30339177) Red vs. brown/black hair color ( 30531825)
Interacting Genes		40 interacting genes: BACE1 BIRC6 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 EPS15 GRAP2 GRB2 H2AC20 H2BC21 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	9 interacting genes: CHMP1B LNPK NR1I2 STAMBP UBE2I USP8 VPS4A VPS4B ZDHHC17
Entrez ID		9101	5119
HPRD ID		04405	01237
Ensembl ID		ENSG00000138592	ENSG00000131165
Uniprot IDs		A0A024R5S4 A8K8N5 P40818	Q9HD42
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09	2JQ9 2YMB 4A5X
Enriched GO Terms of Interacting Partners?
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