SHANK1 and ADGRL1

Number of citations of the paper that reports this interaction (PubMedID 10964907)
21

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SHANK1	ADGRL1
Description		SH3 and multiple ankyrin repeat domains 1	adhesion G protein-coupled receptor L1
Image			No pdb structure
GO Annotations	Cellular Component	Cell Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Cell Junction Axon Growth Cone Presynaptic Membrane Neuron Projection Synapse
	Molecular Function	Protein Binding Protein C-terminus Binding SH3 Domain Binding Receptor Signaling Complex Scaffold Activity GKAP/Homer Scaffold Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding	G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding
	Biological Process	Cytoskeletal Anchoring At Plasma Membrane Synapse Assembly Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Righting Reflex Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Synapse Assembly Positive Regulation Of Synapse Maturation
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Clozapine-induced cytotoxicity ( 25656473)
Interacting Genes		18 interacting genes: ABCA1 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8	9 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2
Entrez ID		50944	22859
HPRD ID		05413	14305
Ensembl ID		ENSG00000161681	ENSG00000072071
Uniprot IDs		H9KV90 Q9Y566	O94910
PDB IDs		6CPI
Enriched GO Terms of Interacting Partners?
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