SHANK1 and TANC1

Number of citations of the paper that reports this interaction (PubMedID 15673434)
5

Data Source:
HPRD (in vitro)

		SHANK1	TANC1
Description		SH3 and multiple ankyrin repeat domains 1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cell Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Postsynaptic Density Cell Junction Dendrite Neuronal Cell Body Axon Terminus
	Molecular Function	Protein Binding Protein C-terminus Binding SH3 Domain Binding Receptor Signaling Complex Scaffold Activity GKAP/Homer Scaffold Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding	Protein Binding
	Biological Process	Cytoskeletal Anchoring At Plasma Membrane Synapse Assembly Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Righting Reflex Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Myoblast Fusion Visual Learning Dendritic Spine Maintenance
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Clozapine-induced cytotoxicity ( 25656473)	Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Nicotine dependence ( 28440896) Night sleep phenotypes ( 27126917) Response to radiotherapy in prostate cancer (toxicity) ( 24974847) Resting heart rate ( 27798624) Restless legs syndrome ( 29029846) Tourette syndrome ( 30818990)
Interacting Genes		18 interacting genes: ABCA1 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8	12 interacting genes: ACTB CAMK2A CASK DLG1 DLG4 DLGAP1 GRIA1 GRIN2B HOMER1 INA SHANK1 SPTAN1
Entrez ID		50944	85461
HPRD ID		05413	18146
Ensembl ID		ENSG00000161681	ENSG00000115183
Uniprot IDs		H9KV90 Q9Y566	B9EK39 Q9C0D5
PDB IDs		6CPI
Enriched GO Terms of Interacting Partners?
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