PBX3 and MEIS1

Number of citations of the paper that reports this interaction (PubMedID 15466398)
36

Data Source:
HPRD (in vitro)

		PBX3	MEIS1
Description		PBX homeobox 3	Meis homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Transcription Factor Complex	Nuclear Chromatin Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Anterior Compartment Pattern Formation Posterior Compartment Specification Respiratory Gaseous Exchange Adult Locomotory Behavior Dorsal Spinal Cord Development Positive Regulation Of Transcription By RNA Polymerase II Neuron Development	Angiogenesis Lens Morphogenesis In Camera-type Eye Locomotory Behavior Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Dentures ( 31235808) Medication use (opioids) ( 31015401) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pulse pressure ( 30578418) Response to mTOR inhibitor (everolimus) ( 24009623) Sleep duration ( 30531941) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418)	Adolescent idiopathic scoliosis ( 28334814) Chronotype ( 30696823) Coffee consumption ( 31046077) Colorectal cancer (diet interaction) ( 24743840) Early spontaneous preterm birth ( 31194736) Endometriosis ( 27506219) Glaucoma (primary open-angle) ( 29891935) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Insomnia ( 27992416) Insomnia complaints ( 28604731) Insomnia complaints (continuous) ( 28604731) Insomnia complaints (dichotomous) ( 28604731) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Morning person ( 30696823) Photic sneeze reflex ( 27182965) PR interval ( 30679814 30046033 20062060 23139255 21347284) PR segment ( 24850809) Relative amplitude of rest-activity cycles ( 30120083) Resting heart rate ( 27798624) Restless legs syndrome ( 17637780 29029846 21779176) Sleep duration ( 30531941) Sleep traits (multi-trait analysis) ( 27992416) Systolic blood pressure ( 30224653 30578418) Triglycerides ( 30275531) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		15 interacting genes: AGTRAP ARL6IP1 CNTRL FSD2 HOXA9 HOXB8 MAGEA1 MAGEC2 MAL2 MEIS1 RABAC1 TPM3 TRAF1 TRIM44 ZNHIT3	27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		5090	4211
HPRD ID		15938	03442
Ensembl ID		ENSG00000167081	ENSG00000143995
Uniprot IDs		P40426 Q5JS98 Q96AL5	O00470
PDB IDs			4XRS 5EGO
Enriched GO Terms of Interacting Partners?
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