MEIS1 and HOXD13

Number of citations of the paper that reports this interaction (PubMedID 15617687)
25

Data Source:
HPRD (in vivo, two hybrid)

		MEIS1	HOXD13
Description		Meis homeobox 1	homeobox D13
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Transcription Factor Complex	Nuclear Chromatin Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity
	Biological Process	Angiogenesis Lens Morphogenesis In Camera-type Eye Locomotory Behavior Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis	Skeletal System Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Multicellular Organism Development Anterior/posterior Pattern Specification Male Genitalia Development Response To Testosterone Regulation Of Cell Proliferation Embryonic Digit Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hindgut Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Morphogenesis Of An Epithelial Fold Branch Elongation Of An Epithelium Regulation Of Branching Involved In Prostate Gland Morphogenesis
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases			Brachydactyly, including: type A; type B; type D; type E Syndactyly Brachydactyly-syndactyly syndrome Synpolydactyly
GWAS		Adolescent idiopathic scoliosis ( 28334814) Chronotype ( 30696823) Coffee consumption ( 31046077) Colorectal cancer (diet interaction) ( 24743840) Early spontaneous preterm birth ( 31194736) Endometriosis ( 27506219) Glaucoma (primary open-angle) ( 29891935) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Insomnia ( 27992416) Insomnia complaints ( 28604731) Insomnia complaints (continuous) ( 28604731) Insomnia complaints (dichotomous) ( 28604731) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Morning person ( 30696823) Photic sneeze reflex ( 27182965) PR interval ( 30679814 30046033 20062060 23139255 21347284) PR segment ( 24850809) Relative amplitude of rest-activity cycles ( 30120083) Resting heart rate ( 27798624) Restless legs syndrome ( 17637780 29029846 21779176) Sleep duration ( 30531941) Sleep traits (multi-trait analysis) ( 27992416) Systolic blood pressure ( 30224653 30578418) Triglycerides ( 30275531) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Male-pattern baldness ( 28196072)
Interacting Genes		27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	5 interacting genes: CREBBP MEIS1 SMAD1 SMAD2 SMAD5
Entrez ID		4211	3239
HPRD ID		03442	00872
Ensembl ID		ENSG00000143995	ENSG00000128714
Uniprot IDs		O00470	P35453
PDB IDs		4XRS 5EGO
Enriched GO Terms of Interacting Partners?
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