MEIS1 and HOXA13

Number of citations of the paper that reports this interaction (PubMedID 15617687)
25

Data Source:
HPRD (two hybrid, in vivo)

		MEIS1	HOXA13
Description		Meis homeobox 1	homeobox A13
Image
GO Annotations	Cellular Component	Nuclear Chromatin Transcription Factor Complex	Nuclear Chromatin Nucleoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding
	Biological Process	Angiogenesis Lens Morphogenesis In Camera-type Eye Locomotory Behavior Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis	Skeletal System Development Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases			Hand-foot-genital syndrome Guttmacher syndrome
GWAS		Adolescent idiopathic scoliosis ( 28334814) Chronotype ( 30696823) Coffee consumption ( 31046077) Colorectal cancer (diet interaction) ( 24743840) Early spontaneous preterm birth ( 31194736) Endometriosis ( 27506219) Glaucoma (primary open-angle) ( 29891935) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Insomnia ( 27992416) Insomnia complaints ( 28604731) Insomnia complaints (continuous) ( 28604731) Insomnia complaints (dichotomous) ( 28604731) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Morning person ( 30696823) Photic sneeze reflex ( 27182965) PR interval ( 30679814 30046033 20062060 23139255 21347284) PR segment ( 24850809) Relative amplitude of rest-activity cycles ( 30120083) Resting heart rate ( 27798624) Restless legs syndrome ( 17637780 29029846 21779176) Sleep duration ( 30531941) Sleep traits (multi-trait analysis) ( 27992416) Systolic blood pressure ( 30224653 30578418) Triglycerides ( 30275531) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Hepatitis B surface antigen seroclearance in chronic hepatitis B infection ( 29975729) Metabolite levels ( 23823483)
Interacting Genes		27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B	6 interacting genes: MEIS1 MEIS2 MEIS3 SMAD1 SMAD2 SMAD5
Entrez ID		4211	3209
HPRD ID		03442	00847
Ensembl ID		ENSG00000143995	ENSG00000106031
Uniprot IDs		O00470	P31271 Q6DI00
PDB IDs		4XRS 5EGO	2L7Z
Enriched GO Terms of Interacting Partners?
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