OAS2 and CLK3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		OAS2	CLK3
Description		2'-5'-oligoadenylate synthetase 2	CDC like kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Acrosomal Vesicle Nucleus Nucleoplasm Membrane Nuclear Speck Intermediate Filament Cytoskeleton
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding	RNA Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process RNA Catabolic Process Response To Virus Response To Bacterium Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity Regulation Of Lactation	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling
Drugs			5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Diseases
GWAS		Adult asthma ( 27611488) Body mass index ( 26426971) Coffee consumption ( 29367735) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Thalamus volume ( 31530798) Visceral adipose tissue adjusted for BMI ( 22589738)	Bladder cancer ( 25281661) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Celiac disease ( 22057235) Craniofacial microsomia ( 26853712)
Interacting Genes		2 interacting genes: APP CLK3	19 interacting genes: APP CLK2 HOXB6 HOXB7 KRTAP10-3 NEDD4 OAS2 PRMT5 RBMX RBMY1A1 RBMY1F RSRP1 SDCBP SLAMF7 SRPK2 SUV39H1 TINF2 YWHAG ZNF263
Entrez ID		4939	1198
HPRD ID		04518	04290
Ensembl ID		ENSG00000111335	ENSG00000179335
Uniprot IDs		P29728 Q7Z6D0	B3KRI8 P49761
PDB IDs			2EU9 2EXE 2WU6 2WU7 3RAW 6FT7 6FYP 6FYR 6KHF 6RCT
Enriched GO Terms of Interacting Partners?
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